| Earned run average | Wins | Strikeouts | Luis Avilan | 3.03 | Felix Hernandez | 158-145 | Felix Hernandez | 2341 | Cal Eldred | 3.66 | Denny Neagle | 114-105 | Denny Neagle | 1462 | Jimmy Key | 3.89 | Andy Pettitte | 113-86 | Ben Sheets | 1217 | Gavin Floyd | 3.93 | Ben Sheets | 84-87 | Andy Pettitte | 1068 | Tommy Hunter | 3.93 | Gavin Floyd | 80-44 | Gavin Floyd | 847 | Felix Hernandez | 3.98 | Jimmy Key | 63-53 | Jason Bere | 822 | Tom Gorzelanny | 3.99 | Jason Bere | 59-67 | Jimmy Key | 782 | Jose Mesa | 4.05 | Livan Hernandez | 50-77 | Tyson Ross | 742 | Andy Pettitte | 4.14 | Jose Mesa | 49-53 | Livan Hernandez | 739 | Ben Sheets | 4.30 | Jason Marquis | 47-52 | Brett Myers | 643 | Winning percentage | Losses | Walks | Gavin Floyd | .645 | Felix Hernandez | 158-145 | Felix Hernandez | 795 | Andy Pettitte | .568 | Denny Neagle | 114-105 | Denny Neagle | 652 | Jimmy Key | .543 | Ben Sheets | 84-87 | Andy Pettitte | 590 | Jeremy Guthrie | .531 | Andy Pettitte | 113-86 | Jason Bere | 547 | Tom Gorzelanny | .529 | Livan Hernandez | 50-77 | Livan Hernandez | 447 | Ervin Santana | .525 | Jason Bere | 59-67 | Ken Hill | 444 | Tommy Hunter | .524 | Ken Hill | 44-62 | Tyson Ross | 407 | Felix Hernandez | .521 | Brett Myers | 41-60 | Jimmy Key | 365 | Denny Neagle | .521 | Jose Mesa | 49-53 | Jason Marquis | 360 | Cal Eldred | .517 | Jimmy Key | 63-53 | Ben Sheets | 341 | Walks plus hits per inning | Runs created ERA | Strikeout/walk ratio | Gavin Floyd | 1.23 | Luis Avilan | 3.28 | Ben Sheets | 3.6 | Tommy Hunter | 1.24 | Gavin Floyd | 3.57 | Felix Hernandez | 2.9 | Felix Hernandez | 1.28 | Felix Hernandez | 3.80 | Tommy Hunter | 2.9 | Luis Avilan | 1.29 | Tommy Hunter | 3.89 | Gavin Floyd | 2.6 | Ben Sheets | 1.32 | Tom Gorzelanny | 4.01 | Tom Gorzelanny | 2.4 | Jimmy Key | 1.33 | Jeremy Guthrie | 4.41 | Bill Wegman | 2.4 | Denny Neagle | 1.34 | Ben Sheets | 4.43 | Jay Witasick | 2.3 | Cal Eldred | 1.35 | Aaron Sanchez | 4.43 | Denny Neagle | 2.2 | Tom Gorzelanny | 1.37 | Jordan Lyles | 4.58 | Luis Avilan | 2.2 | Bill Wegman | 1.39 | Tyson Ross | 4.63 | Jimmy Key | 2.1 | Hits per 9 innings | Strikeouts per 9 innings | Walks per 9 innings | Luis Avilan | 7.9 | Jay Witasick | 8.7 | Bill Wegman | 1.9 | Gavin Floyd | 8.4 | Tyson Ross | 8.2 | Ben Sheets | 2.1 | Cal Eldred | 8.6 | Lucas Giolito | 8.2 | Tommy Hunter | 2.2 | Lucas Giolito | 8.6 | Tom Gorzelanny | 8.2 | Mike Maroth | 2.6 | Felix Hernandez | 8.8 | Felix Hernandez | 8.1 | Jeremy Guthrie | 2.7 | Tyson Ross | 8.8 | Luis Avilan | 7.9 | Gavin Floyd | 2.7 | Tommy Hunter | 8.9 | Ben Sheets | 7.6 | Felix Hernandez | 2.7 | Jason Bere | 8.9 | Brett Myers | 7.5 | Jimmy Key | 2.8 | Tom Gorzelanny | 9.0 | Russ Ortiz | 7.4 | Justin Nicolino | 2.8 | Aaron Sanchez | 9.1 | Gavin Floyd | 7.0 | Denny Neagle | 2.9 | Innings | Starts | Complete games | Felix Hernandez | 2613.2 | Felix Hernandez | 394 | Felix Hernandez | 56 | Denny Neagle | 2025.0 | Denny Neagle | 282 | Denny Neagle | 51 | Andy Pettitte | 1668.0 | Andy Pettitte | 225 | Andy Pettitte | 50 | Ben Sheets | 1433.0 | Ben Sheets | 214 | Jimmy Key | 32 | Jimmy Key | 1178.1 | Jason Bere | 167 | Ben Sheets | 30 | Livan Hernandez | 1089.2 | Jimmy Key | 162 | Cal Eldred | 25 | Gavin Floyd | 1085.2 | Livan Hernandez | 159 | Livan Hernandez | 25 | Jason Bere | 1085.1 | Gavin Floyd | 157 | Ken Hill | 23 | Ken Hill | 926.1 | Jason Marquis | 137 | Gavin Floyd | 15 | Jason Marquis | 816.2 | Ken Hill | 135 | Mike Maroth | 11 | Shutouts | Quality starts | Quality start percentage | Felix Hernandez | 26 | Felix Hernandez | 222 | Gavin Floyd | .605 | Andy Pettitte | 12 | Ben Sheets | 113 | Felix Hernandez | .563 | Denny Neagle | 9 | Gavin Floyd | 95 | Tom Gorzelanny | .536 | Jimmy Key | 8 | Tyson Ross | 68 | Jordan Lyles | .532 | Ben Sheets | 8 | Jordan Lyles | 66 | Tyson Ross | .531 | Cal Eldred | 4 | Jason Marquis | 62 | Ben Sheets | .528 | Gavin Floyd | 4 | Brett Myers | 55 | Jeremy Guthrie | .511 | Jake Westbrook | 3 | Jeremy Guthrie | 48 | Jeff Locke | .500 | Mike Maroth | 3 | Jeff Locke | 47 | Tommy Hunter | .462 | Jeremy Guthrie | 3 | Tom Gorzelanny | 37 | Jason Marquis | .453 | Save Opportunities | Saves | Blown saves | Jose Mesa | 237 | Jose Mesa | 181 | Jose Mesa | 54 | Bob Wickman | 204 | Bob Wickman | 165 | Bob Wickman | 35 | Jim Johnson | 113 | Jim Johnson | 94 | Luis Avilan | 21 | Shane Greene | 67 | J.J. Putz | 49 | Michael Wuertz | 21 | Michael Wuertz | 67 | Shane Greene | 48 | Shane Greene | 19 | J.J. Putz | 61 | Alex Wilson | 42 | Jim Johnson | 19 | Alex Wilson | 59 | Michael Wuertz | 42 | Pedro Baez | 18 | Brad Boxberger | 52 | Cory Wade | 41 | Tommy Hunter | 18 | Tommy Hunter | 52 | Brad Boxberger | 39 | Alex Wilson | 14 | Pedro Baez | 51 | Tommy Hunter | 33 | 2 tied with | 13 | Games | Homeruns | Hit by pitch | Jose Mesa | 512 | Felix Hernandez | 284 | Felix Hernandez | 101 | Felix Hernandez | 395 | Denny Neagle | 274 | Denny Neagle | 64 | Luis Avilan | 335 | Ben Sheets | 178 | Jordan Lyles | 48 | Tommy Hunter | 322 | Andy Pettitte | 146 | Jason Bere | 46 | Denny Neagle | 321 | Brett Myers | 134 | Tyson Ross | 45 | Bob Wickman | 315 | Livan Hernandez | 130 | Andy Pettitte | 42 | Hector Carrasco | 276 | Gavin Floyd | 122 | Jason Marquis | 40 | Mike Jackson | 272 | Jason Bere | 111 | Gavin Floyd | 39 | Alex Wilson | 259 | Ken Hill | 105 | Ben Sheets | 36 | Jay Witasick | 253 | Jason Marquis | 105 | Livan Hernandez | 33 |